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Research has also been directed at establishing associations between specific single-nucleotide polymorphisms SNP or haplotypes with either higher or lower HDL-C, in the presence or absence of atherosclerosis [ 55 ]. Post hoc analysis of data from the Treating to New Targets Study, a multicentric, randomized, double-blind study which assessed the predictive value of HDL-C in 9, subjects with established CVD on statin therapy. The molecular mechanisms involved in these phenomena are detailed in the following sections. The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. For details, see the text. Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-I.
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