Despite the fact that Alex Turner, the band's frontman, has laryngitis, Arctic Monkeys are expected to perform their headlining set at Glastonbury on Friday.
This week, the band postponed a performance in Dublin, raising concerns about their readiness for the festival.
However, Emily Eavis assured the BBC that Turner would survive. She assured him that everything would be fine and that he was recovering.
If not, we have a couple of fallback options, she added.
"For everything, we always have a backup plan. " .
It will be the Sheffield band's third time at the top of the bill, following its appearances in 2008 and 2013.
They join Radiohead, The Cure, Van Morrison, and Elvis Costello in the exclusive club of triple headliners.
With headlining performances in 2002, 2005, 2011, and 2016, only Coldplay has progressed further.
According to drummer Matt Helders of Arctics, "Hopefully it gets easier every time, in terms of nerves.".
Turner claimed, just before he became ill, that the band was better prepared than ever for the festival.
Naturally, we felt the pressure the most the first time. When it happened again, it was at the start of a tour, so it was enjoyable but we hadn't been performing beforehand.
"This time, we are involved. In the midst of a tour, we're in a good spot. We're working hard right now. " (. Continue reading the interview with Matt Helders by scrolling down. ).
There are a number of possible replacements if the band is forced to cancel.
One of them is the "mystery band" that will perform on the Pyramid Stage on Friday night.
They are billed as The ChurnUps, a band with no online presence and no music available for streaming.
Following frontman Dave Grohl's social media post in which he discussed "churning up" emotions as the band tours without late drummer Taylor Hawkins for the first time, fans have speculated that they are actually US rock band Foo Fighters.
Other rumors have focused on Britpop icons Pulp and Blur, both of whom were former headliners and are currently on a reunion tour this summer.
Eavis refused to answer questions about the rumors.
She resisted the urge to give anything away. "You have to let the surprise happen. The surprise is the key. ".
Eavis spoke as Glastonbury's gates opened on Wednesday morning. 200,000 people were expected to attend performances by Sir Elton John, Lana Del Rey, Guns N' Roses, Wizkid, and Christine & the Queens.
Weather warnings have been issued for the festival due to the weekend's predicted high of 27 degrees.
In keeping with its long-standing commitment to sustainability, free water is available everywhere on the site, which is now exclusively powered by renewable energy.
On Thursday, the on-stage action gradually ramped up with DJ sets by Faithless, Mike Skinner, Nia Archives, Ewan McVicar, and Arielle Free warming up the numerous smaller stages that are scattered throughout the venue.
In addition, festival founder Michael Eavis, 88, performed a surprise mid-afternoon set on The Park Stage with his band, covering classic songs like My Way, Always On My Mind, and Send In The Clowns.
The music on the main stages will begin at 11:30 on Friday when singer-songwriter Ben Howard debuts The Other Stage.
Afrobeats superstar Wizkid (Other Stage, 22:30), jazz psychedelic band The Comet Is coming (Park Stage, 1815), Scottish rock band Texas (Pyramid Stage, 16:15), and US R&B star Kelis (West Holts, 22:15) are also on the Friday lineup.
Eli Crossley, 16, and his band Askew will perform at the Rabbit Hole at 17:30 BST, making them some of the festival's youngest-ever performers.
In response to Eli's interview with the BBC regarding his genetic disorder, Duchenne muscular dystrophy, and his desire to play the festival, Emily Eavis extended an invitation to the band.
On TV, radio, BBC iPlayer, and BBC Sounds, the BBC will air complete sets and festival highlights.
Your third appearance on the Pyramid Stage. Are you eagerly anticipating it?
It's good, and hopefully the nerves will lessen each time. We'll be playing better than we have in the past because of where we are in the touring cycle, which is always a good thing.
Additionally, it has been 10 years since we last performed it, making this a full circle celebration.
You've previously performed with a string quartet and welcomed Dizzee Rascal as a special guest. Any surprises this time around?
In addition to the custom of having a special guest or performing something extra special at Glastonbury, I believe there is much to be said for simply putting on an excellent performance.
The response to your most recent album, The Car, has been phenomenal. It was named the year's best album by The NME. Before it was published, how confident were you?
There were some songs that I had a lot of faith in, and we actually sat on it for a while before it was released. I was aware that Sculptures Of Anything Goes and [There'd Better Be A] Mirrorball would be exceptional. We had taken our time to make sure it was what we wanted. We would have believed we had acted improperly if we had been unsure at that point.
With rockier songs like Brianstorm and RU Mine, Alex claimed he had intended to create an album. Why did things turn out the way they did?
We frequently have that goal in mind when we enter the studio because those songs really stand out when we perform them live. That was enjoyable to play, we think. More songs with that vibe should be released.
However, songwriting is not always something that comes naturally. You can write the riff, but it's hard to fake sincerity while doing so.
You claimed to Radio 1 last year that the new songs are "trickier" to play because of their subtlety compared to the older music. How have things been on the tour?
It can be challenging to hold back when recording, and this problem carries over to live performances as well because it's easy to get giddy and want to flaunt your skills.
However, there are times during the performance when I get to satisfy that itch. We'll play all the action-packed songs before things take a short break. The balance is excellent.
Which of the brand-new songs will you be playing?
Currently, I would choose Body Paint because, speaking of dynamics, it really comes to life at the end. I decide how long and how intense it will be after we just sort of wig out a little bit. It's nice to enjoy it a little bit more.
RU Mine, a real workout on the drums, frequently ends the set. Do you need to conserve some energy?
You know, we added that last night halfway through the set, and it felt strange to play it there. By the end of the performance, I frequently rely on adrenaline, but I also would struggle if that song had been the opener because I get more comfortable as the show goes on.
You run the risk of tearing a muscle if you don't.
Exactly. Near the beginning, we frequently play Brianstorm, so I have to work to control my tension because of this. I do attempt to stretch and play a little drum backstage. I haven't been disciplined or good at forcing myself to do that, though. I desire a wide social circle.
Is it accurate to say that you purchased a bar?
I gave something. I feel like I'm a part of this Sheffield establishment called Fagan's now. [Matt] was one of nine investors who stepped in to save the business when it was in danger of closing last year.
Can you however pull a pint?
I've attempted to learn how to pour a pint of Guinness in the shapes.
