According to reports from the BBC, the Magee campus of Ulster University will receive millions in funding from the Irish government to help increase enrollment.
It is one of several international projects whose funding is anticipated to be approved by the Irish cabinet later on Tuesday.
For a new teaching and student services building, the Londonderry campus is anticipated to receive €45 million (£38.4 million).
Through the Shared Island Unit of the government, the funding is made available.
To deliver island-wide investment projects, it was founded in 2020.
The Irish government is anticipated to announce funding for a number of additional international initiatives, including a new island-wide youth forum and a respite and therapeutic facility for kids with cancer.
It has long been believed that the expansion of the university in Derry will spur regional economic growth.
The agreement known as "New Decade, New Approach," which restored Northern Ireland's power-sharing executive in 2020, states that both the Irish and UK governments will work to provide financial support for Ulster University's 10,000 student target growth.
According to what is known, the funding from the Irish government will also assist the Atlantic Technological University Donegal, which has campuses in Letterkenny and Killybegs, and the Derry campus in developing closer ties.
The BBC understands that the Dublin government will ultimately approve spending of more than €50 million (£42 point 7 million).